CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes.

@article{Kuniyasu2003CD36mediatedEU,
  title={CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes.},
  author={Akihiko Kuniyasu and Nobutaka Ohgami and Shigeki Hayashi and Akira Miyazaki and Seikoh Horiuchi and Hitoshi Nakayama},
  journal={FEBS letters},
  year={2003},
  volume={537 1-3},
  pages={85-90}
}
Interaction of advanced glycation end products (AGE) with AGE receptors induces several cellular phenomena potentially relating to diabetic complications. We here show that AGE-modified bovine serum albumin (BSA) is endocytosed by adipocytes via CD36. Upon differentiation, 3T3-L1 and human subcutaneous adipose cells showed marked increases in endocytic uptake and subsequent degradation of [(125)I]AGE-BSA, which were inhibited effectively by the anti-CD36 antibody. Ligand specificity of CD36 for… CONTINUE READING

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