CD36 is a ditopic glycoprotein with the N-terminal domain implicated in intracellular transport.

@article{Gruarin2000CD36IA,
  title={CD36 is a ditopic glycoprotein with the N-terminal domain implicated in intracellular transport.},
  author={Paola Gruarin and Rick Francis Thorne and Douglas J. Dorahy and Gordon F. Burns and Roberto Sitia and Massimo Alessio},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={275 2},
  pages={446-54}
}
The CD36 receptor sequence predicts two hydrophobic domains located at the N- and C-termini of the protein, but there are conflicting reports as to whether the N-terminal uncleaved leader sequence functions as a transmembrane domain. To investigate the topology of CD36, we generated a panel of mutants lacking either one or both hydrophobic regions and analyzed their folding and transport in COS-7 cells. The N- and the C-terminal hydrophobic regions were both sufficient to anchor CD36 in the… CONTINUE READING