CD36 initiated signaling mediates ceramide-induced TXNIP expression in pancreatic beta-cells.

@article{Karunakaran2015CD36IS,
  title={CD36 initiated signaling mediates ceramide-induced TXNIP expression in pancreatic beta-cells.},
  author={Udayakumar Karunakaran and Jun Sung Moon and Hyoung Woo Lee and Kyu Chang Won},
  journal={Biochimica et biophysica acta},
  year={2015},
  volume={1852 11},
  pages={
          2414-22
        }
}
Diverse mechanisms are involved in the pathogenesis of β-cell failure in type 2 diabetes. Of them, the accumulation of ceramide, a bioactive lipid metabolite, is suggested to play a major role in inflammatory and stress responses that induce diabetes. However, the downstream inflammatory target of ceramide has not been defined. Using rat islets and the INS-1 β-cell line, we hypothesized that activation of the redox sensitive protein TXNIP is involved in ceramide-induced β-cell dysfunction… CONTINUE READING