CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free-feeding mice.

@article{Guijarro2010CD36GD,
  title={CD36 gene deletion decreases oleoylethanolamide levels in small intestine of free-feeding mice.},
  author={Ana Isabel Guijarro and Jiamei Fu and Giuseppe Astarita and Daniele Piomelli},
  journal={Pharmacological research},
  year={2010},
  volume={61 1},
  pages={27-33}
}
Oleoylethanolamide (OEA) is an endogenous lipid mediator that decreases food intake and enhances lipid catabolism. Dietary fat stimulates OEA mobilization in the proximal small intestine, through a mechanism that requires the participation of the membrane glycoprotein CD36 (fatty acid translocase, FAT). CD36 is highly expressed in small-intestinal enterocytes and is involved in fatty acid uptake and intracellular signaling. Here, we analyze the impact of genetic CD36 deletion on OEA production… CONTINUE READING

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