CD36-facilitated fatty acid uptake inhibits leptin production and signaling in adipose tissue.

@article{Hajri2007CD36facilitatedFA,
  title={CD36-facilitated fatty acid uptake inhibits leptin production and signaling in adipose tissue.},
  author={Tahar Hajri and Angela M. Hall and Dalan R. Jensen and Terri A. Pietka and Victor A B Drover and Huan Tao and Robert W. Eckel and Nada A. Abumrad},
  journal={Diabetes},
  year={2007},
  volume={56 7},
  pages={1872-80}
}
Leptin plays an important role in regulating energy expenditure in response to food intake, but nutrient regulation of leptin is incompletely understood. In this study using in vivo and in vitro approaches, we examined the role of fatty acid uptake in modulating leptin expression and production. Leptin levels are doubled in the CD36-null mouse, which has impaired cellular fatty acid uptake despite a 40% decrease in fat mass. The CD36-null mouse is protected from diet-induced weight gain but not… CONTINUE READING