CD34- hematopoietic stem cells: current concepts and controversies.

  title={CD34- hematopoietic stem cells: current concepts and controversies.},
  author={Yalin Guo and Michael Luebbert and Monika Engelhardt},
  journal={Stem cells},
  volume={21 1},
Recent data have suggested that human CD34(-) hematopoietic stem cells (HSCs) exist, challenging the concept that HSCs necessarily and exclusively express the CD34 antigen. In mice, quiescent HSCs have been shown to be mostly CD34(-), but as a consequence of 5-fluorouracil treatment or cytokine stimulation, differentiate into CD34(+) cells. Of particular interest is a novel, specific marker to identify HSCs, namely the Hoechst dye efflux property, with which a distinct side population (SP) is… CONTINUE READING
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