CD34 expression is associated with poor survival in pediatric T-cell acute lymphoblastic leukemia.

@article{Grotel2008CD34EI,
  title={CD34 expression is associated with poor survival in pediatric T-cell acute lymphoblastic leukemia.},
  author={Martine van Grotel and Marry M van den Heuvel-Eibrink and Elisabeth R van Wering and Max M. van Noesel and Willem A. Kamps and Anjo J. P. Veerman and Rob Pieters and Jules P P Meijerink},
  journal={Pediatric blood & cancer},
  year={2008},
  volume={51 6},
  pages={737-40}
}
BACKGROUND Children with T-lineage acute lymphoblastic leukemia (T-ALL) have an inferior outcome with combination chemotherapy compared to B-lineage ALL, and still about 30% of the patients relapse within the first 2 years following diagnosis. As CD34 has been related with poor outcome in ALL in general, we investigated the prognostic significance of the stem cell marker CD34, as well as the association of CD34 positivity with the expression of several multidrug resistance (MDR) genes… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 13 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 24 references

Prognostic significance of molecular - cytogenetic abnormalities in pediatric tall is not explained by immunophenotypic differences

CI Civin, LC Strauss, C Brovall
Leukemia • 2008

Prognostic significance of multidrug resistance-related proteins in childhood acute lymphoblastic leukaemia

K Swerts, B De Moerloose, C Dhooge
Eur J Cancer 2006;42:295–309 • 2006
View 1 Excerpt

The outcome of molecular-cytogenetic subgroups in pediatric t-cell acute lymphoblastic leukemia: A retrospective study of patients treated according to dcog or coall protocols

M van Grotel, JP Meijerink, HB Beverloo
Haematologica • 2006
View 1 Excerpt

Comparison of two functional flow cytometric assays to assess p-gp activity in acute leukemia

K Swerts, B de Moerloose, C Dhooge
Leuk Lymphoma • 2004

Similar Papers

Loading similar papers…