CD34 expression is associated with poor survival in pediatric T-cell acute lymphoblastic leukemia.

  title={CD34 expression is associated with poor survival in pediatric T-cell acute lymphoblastic leukemia.},
  author={Martine van Grotel and Marry M van den Heuvel-Eibrink and Elisabeth R van Wering and Max M. van Noesel and Willem A. Kamps and Anjo J. P. Veerman and Rob Pieters and Jules P P Meijerink},
  journal={Pediatric blood & cancer},
  volume={51 6},
BACKGROUND Children with T-lineage acute lymphoblastic leukemia (T-ALL) have an inferior outcome with combination chemotherapy compared to B-lineage ALL, and still about 30% of the patients relapse within the first 2 years following diagnosis. As CD34 has been related with poor outcome in ALL in general, we investigated the prognostic significance of the stem cell marker CD34, as well as the association of CD34 positivity with the expression of several multidrug resistance (MDR) genes… CONTINUE READING


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