CD34‐positive fibroblasts in Reinke's edema

@article{DazFlores2014CD34positiveFI,
  title={CD34‐positive fibroblasts in Reinke's edema},
  author={Lucio D{\'i}az-Flores and Ricardo Guti{\'e}rrez and Mar{\'i}a del Pino Garc{\'i}a and Hugo {\'A}lvarez‐Arg{\"u}elles and Daniel L{\'o}pez-Campos},
  journal={The Laryngoscope},
  year={2014},
  volume={124}
}
To elucidate whether and to what extent CD34+ fibroblasts (so‐called CD34+ fibrocytes, CD34+ dendritic cells, and CD34+ stromal cells) occur in normal human vocal folds and in Reinke's edema. 

Human resident CD34+ stromal cells/telocytes have progenitor capacity and are a source of αSMA+ cells during repair.

Human resident CD34+ SC/TCs in the enteric wall have progenitor capacity and are activated with or without differentiation into αSMA+ stromal cells during inflammatory/repair processes.

Telocyte Behaviour During Inflammation, Repair and Tumour Stroma Formation.

The role of human CD34+ stromal cells/telocytes (CD34+ SC/TCs) as progenitor cells during repair is outlined and their behaviour in vivo and in vitro and different behaviour depending on location, time, type of injury are considered.

Cd34+ Stromal Cells/Telocytes in Normal and Pathological Skin

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Proliferation of Interstitial Cells in the Cyclophosphamide-Induced Cystitis and the Preventive Effect of Imatinib

Urethritis may contribute to the uropathology of CYP-induced cystitis, as similar results were obtained in the urethra, and Pretreatment with the receptor tyrosine kinase inhibitor Imatinib prevented eNOS expression and ICs proliferation.

Behavior of In Situ Human Native Adipose Tissue CD34+ Stromal/Progenitor Cells During Different Stages of Repair. Tissue‐Resident CD34+ Stromal Cells as a Source of Myofibroblasts

Observations point to human adipose tissue‐resident CD34+ stromal cells as an important source of myofibroblasts during inflammatory/repair processes at different stages of evolution.

Reinke's edema management and voice outcomes

This review provides perspectives on current and future management of Reinke's edema, a cause of chronic dysphonia that is difficult to manage.

Hyaluronic Acid Concentration in Female Vocal Folds With Reinke’s Edema

Vocal fold covers affected by Reinke’s edema present a higher concentration of HA than do vocal fold covers with no edema, and this concentration was significantly higher than that in the control vocal folds.

References

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Stromal remodeling precipitated by invasive carcinomas is characterized by a loss of CD34(+) expression paralleled by a gain of alpha-SMA expression in stromal cells resulting in a phenotype change from CD34 (+) fibrocytes towards alpha- SMA positive myofibroblasts, which may play an essential role in local tumor invasion and systemic dissemination.

Disarrangement of Collagen Fibers in Reinke's Edema

Objective/Hypothesis: To describe the arrangement of collagen fibers in the superficial layer of the lamina propria of the vocal folds with Reinke' edema with the help of X-ray diffraction analysis.

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Reinke's Edema: investigations on the role of MIB-1 and hepatocyte growth factor

MIB-1, on the contrary, showed a weak expression in the basement membrane of the mucosal epithelium and a total absence in the lamina propria deep layer, thus suggesting that only the superficial layer is actively involved in the reparatory process with a high regenerative capacity, together with ahigh deposition of fibronectin.

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Cyclooxygenase‐2 (COX‐2) is an important enzyme involved in both inflammation and fibrosis and it is a prime target for therapeutic intervention in vocal fold fibroblasts.

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Blood-borne fibrocytes contribute to scar formation and may play an important role both in normal wound repair and in pathological fibrotic responses.

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Findings indicate that the hollow spaces of Reinke's edema develop like neobursae from mechanical strain, contradict the concept of lymphatic distension in cases of Reinkes edema.
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