CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation.

  title={CD34+ hemopoietic progenitor cells are potent effectors of allergic inflammation.},
  author={Zoulfia Allakhverdi and Michael R. Comeau and Dirk Smith and Dean Y Toy and Leandra Mfuna Endam and Martin Desrosiers and Yong-Jun Liu and Karen J. Howie and Judah A. Denburg and Gail M Gauvreau and Guy J. Delespesse},
  journal={The Journal of allergy and clinical immunology},
  volume={123 2},
BACKGROUND In steady state, hemopoietic progenitors constantly egress from the bone marrow (BM) into the blood and circulate through the peripheral tissues. In allergic diseases, the BM releases increased numbers of CD34(+) progenitor cells that migrate to the site of allergic inflammation, where they differentiate into tissue-dwelling and classic effector cells of allergy, such as mast cells, eosinophils, and basophils. OBJECTIVE To examine whether peripheral blood CD34(+) cells in addition… CONTINUE READING

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