CD34+ gene expression profiling of individual children with very severe aplastic anemia indicates a pathogenic role of integrin receptors and the proapoptotic death ligand TRAIL.

@article{Fischer2012CD34GE,
  title={CD34+ gene expression profiling of individual children with very severe aplastic anemia indicates a pathogenic role of integrin receptors and the proapoptotic death ligand TRAIL.},
  author={Ute M Fischer and Christian Ruckert and Bernd Hubner and Olaf Eckermann and Vera Binder and Tamam Bakchoul and Friedhelm R. Schuster and Sylvia Merk and Hans-Ulrich Klein and Monika M Fuehrer and Martin Dugas and Arndt Borkhardt},
  journal={Haematologica},
  year={2012},
  volume={97 9},
  pages={1304-11}
}
UNLABELLED BACKGROUND Very severe aplastic anemia is characterized by a hypoplastic bone marrow due to destruction of CD34(+) stem cells by autoreactive T cells. Investigation of the pathomechanism by patient-specific gene expression analysis of the attacked stem cells has previously been impractical because of the scarcity of these cells at diagnosis. DESIGN AND METHODS Employing unbiased RNA amplification, patient-specific gene expression profiling was carried out for CD34(+) cells from… CONTINUE READING