CD33 as a target for selective ablation of acute myeloid leukemia.

@article{Bernstein2002CD33AA,
  title={CD33 as a target for selective ablation of acute myeloid leukemia.},
  author={Irwin D Bernstein},
  journal={Clinical lymphoma},
  year={2002},
  volume={2 Suppl 1},
  pages={S9-11}
}
The CD33 antigen is a 67-kd glycosylated transmembrane protein of the sialic acid-binding immunoglobulinlike lectin (siglec) family with immunoreceptor tyrosine-based inhibitory motifs. It is expressed on the surface of normal mature and immature myeloid cells, including colony-forming progenitor cells, and on leukemic blasts from the majority of patients with acute myeloid leukemia (AML). CD33 is not expressed by the normal stem cells, suggesting that in vivo ablation of CD33-bearing normal… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-8 of 8 extracted citations

Similar Papers

Loading similar papers…