CD30-positive anaplastic large cell lymphoma in childhood: expression of p80npm/alk and absence of Epstein-Barr virus.

@article{Nakagawa1997CD30positiveAL,
  title={CD30-positive anaplastic large cell lymphoma in childhood: expression of p80npm/alk and absence of Epstein-Barr virus.},
  author={Akihiko Nakagawa and Shigeo Nakamura and Masahiro Ito and Mami Shiota and Shigeo Mori and Taizan Suchi},
  journal={Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc},
  year={1997},
  volume={10 3},
  pages={210-5}
}
CD30(+)-anaplastic large cell lymphoma (ALCL) is a distinct clinicopathologic entity of non-Hodgkin's lymphoma that is immunologically heterogeneous. Bimodal age distribution, a nonrandom chromosome abnormality [t(2;5)(p23;q35)] that produces a chimeric protein p80npm/alk, and a variable (5-47%) association with Epstein-Barr virus (EBV) have been reported. We reviewed 36 cases of ALCL (19 were children < 20 yr and 17 were adults) by focusing on the presence or absence of p80npm/alk protein and… CONTINUE READING