CD30 and type 2 T helper (Th2) responses.

  title={CD30 and type 2 T helper (Th2) responses.},
  author={Sergio Romagnani and Gianfranco Del Prete and Enrico Maggi and Marco Chilosi and Federico Caligaris-Cappio and Giovanni Pizzolo},
  journal={Journal of leukocyte biology},
  volume={57 5},
CD30 is one of the members of the tumor necrosis factor receptor superfamily, originally described as a marker of Reed-Sternberg and Hodgkin's cells in Hodgkin's lymphoma. CD30 appears to be preferentially expressed on, and its soluble form (sCD30) released by, CD4+ and CD8+ T cell clones capable of producing T helper 2 (Th2)-type cytokines. In noneoplastic conditions, CD30+ T cells are barely detectable in vivo; however, a few allergen-specific CD4+CD30+ T cells inducible to the production of… CONTINUE READING


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