CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells.

@article{Wright2007CD30AB,
  title={CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells.},
  author={Casey W. Wright and Julie M. Rumble and Colin S. Duckett},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 14},
  pages={10252-62}
}
CD30 is a member of the tumor necrosis factor receptor superfamily whose expression is up-regulated on anaplastic large cell lymphoma (ALCL) and Hodgkin lymphoma (HL) cells. Many different outcomes of CD30 stimulation have been reported, including cell cycle arrest, apoptosis, and activation of the prosurvival transcription factor, NF-kappaB, although this… CONTINUE READING