CD30, Th2 cytokines and HIV infection: a complex and fascinating link.

@article{Prete1995CD30TC,
  title={CD30, Th2 cytokines and HIV infection: a complex and fascinating link.},
  author={Gianfranco Del Prete and Enrico Maggi and Giovanni Pizzolo and Sergio Romagnani},
  journal={Immunology today},
  year={1995},
  volume={16 2},
  pages={76-80}
}
CD30 is a member of the tumor necrosis factor (TNF)/nerve growth factor (NGF) receptor superfamily, and was originally described as a marker of Hodgkin's and Reed-Sternberg cells in Hodgkin's lymphoma. CD30 is preferentially expressed on CD4+ and CD8+ T-cell clones that produce T helper 2 (Th2)-type cytokines, and is also released in a soluble form by these cells. Elevated serum levels of soluble (s)CD30 have been found in some conditions in which a pathogenic role for Th2 cells has been… CONTINUE READING
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