CD30+ T cells in rheumatoid synovitis: mechanisms of recruitment and functional role.

@article{Gerli2000CD30TC,
  title={CD30+ T cells in rheumatoid synovitis: mechanisms of recruitment and functional role.},
  author={Roberto Gerli and Costantino Pitzalis and Onelia Bistoni and Brunangelo Falini and Vincenzo Costantini and Anna Maria Russano and Claudio Lunardi},
  journal={Journal of immunology},
  year={2000},
  volume={164 8},
  pages={4399-407}
}
High serum levels of soluble CD30 (sCD30) have been reported to better predict the response to second line therapy in rheumatoid arthritis (RA). It is believed that sCD30 is released by CD30+ T cells present in the RA synovium. However, both the mechanism of recruitment to the joint and the functional role of this T cell subset in the pathogenesis of the disease remain unknown. This study confirmed higher levels of sCD30 in the serum and synovial fluid (SF) of RA patients compared with normal… CONTINUE READING

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