CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells.

@article{Sancho1992CD3zetaSE,
  title={CD3-zeta surface expression is required for CD4-p56lck-mediated upregulation of T cell antigen receptor-CD3 signaling in T cells.},
  author={Jaime Ferrer Sancho and Jeffrey A. Ledbetter and Moonsuk S. Choi and Steven B. Kanner and Julie P. Deans and Cox Terhorst},
  journal={The Journal of biological chemistry},
  year={1992},
  volume={267 11},
  pages={7871-9}
}
It has been proposed that during T cell receptor antigen recognition, CD4- or CD8-p56lck molecules interact with the T cell antigen receptor-CD3 complex (TCR-CD3) to phosphorylate various undefined substrates, which then initiate signal transduction through the TCR-CD3 complex. The ability of CD4 to modulate the TCR-CD3-induced increase in intracellular Ca2+, [Ca2+]i, and substrate tyrosine phosphorylation was studied in mutants of the human leukemic T cell line HPB-ALL characterized by their… CONTINUE READING