CD3-negative natural killer cells express ε TCR as part of a novel molecular complex

@article{Anderson1989CD3negativeNK,
  title={CD3-negative natural killer cells express ε TCR as part of a novel molecular complex},
  author={Paul N. Anderson and Michael A. Caligiuri and Jerome Ritz and Stuart F. Schlossman},
  journal={Nature},
  year={1989},
  volume={341},
  pages={159-162}
}
NATURAL killer (NK) cells are large granular lymphocytes capable of killing tumour cells in a non-MHC restricted manner1,2. NK cells do not express cell-surface CD3, or any known target recognition structure analogous to the T cell antigen receptor (TCR) heterodimers (αβ or γδ)3–8. Consistent with their lack of expression of a CD3–TCR complex, NK cells do not require prior sensitization or antigen presentation by accessory cells to specifically recognize their tumour targets1. Although NK cells… CONTINUE READING

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