CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice.

@article{Chatenoud1997CD3AD,
  title={CD3 antibody-induced dominant self tolerance in overtly diabetic NOD mice.},
  author={Lucienne Chatenoud and Jaime Primo and J. F. Bach},
  journal={Journal of immunology},
  year={1997},
  volume={158 6},
  pages={2947-54}
}
Low doses of the CD3 mAb 145 2C11 restored self tolerance to beta cell Ags in adult overtly diabetic NOD mice. Within 2 to 4 wk after treatment, complete and permanent remission of diabetes was observed. Autoreactive T cells were not deleted in CD3 Ab-protected animals as evidenced first, by the persistence of peripheral insulitis and, second, by the… CONTINUE READING