CD3⁻NK1.1⁺ cells aid in the early induction of a Th1 response to an attaching and effacing enteric pathogen.

@article{ReidYu2013CD3NK11CA,
  title={CD3⁻NK1.1⁺ cells aid in the early induction of a Th1 response to an attaching and effacing enteric pathogen.},
  author={Sarah A. Reid-Yu and Cherrie-Lee N. Small and Brian K Coombes},
  journal={European journal of immunology},
  year={2013},
  volume={43 10},
  pages={2638-49}
}
Extracellular attaching and effacing (A/E) pathogens including pathogenic Escherichia coli colonize the host gut causing diarrhea and inflammation. Although much is known regarding the pathogenesis of A/E bacteria, there remains an incomplete understanding of host immune responses to these microbes. NK cells are an important source of IFN-γ and are essential for early innate responses to viral pathogens; however, their role during extracellular bacterial infections is still largely unexplored… CONTINUE READING