CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling.

@article{Hannier1998CD3TCRCL,
  title={CD3/TCR complex-associated lymphocyte activation gene-3 molecules inhibit CD3/TCR signaling.},
  author={Sigrid Hannier and Muriel Tournier and Georges Bismuth and Fr{\'e}d{\'e}ric Triebel},
  journal={Journal of immunology},
  year={1998},
  volume={161 8},
  pages={4058-65}
}
The lymphocyte activation gene-3 (LAG-3) molecule is a T cell activation Ag closely related to CD4 at the gene and protein levels. We investigated whether LAG-3 itself may down-regulate the immune response by interfering with TCR signaling. The binding of Ab to the LAG-3 molecule followed by cross-linking (XL) inhibits cell proliferation and cytokine secretion in response to CD3XL on activated T cells. LAG-3XL-induced down-regulation is associated with functional unresponsiveness, as well as… CONTINUE READING
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