CD3/CD28 dynabeads induce expression of tn antigen in human t cells accompanied by hypermethylation of the cosmc promoter.

@article{Shi2017CD3CD28DI,
  title={CD3/CD28 dynabeads induce expression of tn antigen in human t cells accompanied by hypermethylation of the cosmc promoter.},
  author={Chuanqin Shi and Xue Xu and Xiaofeng Yu and Zhenzhen Du and Xi-ying Luan and Dachang Liu and Tao Hu},
  journal={Molecular immunology},
  year={2017},
  volume={90},
  pages={98-105}
}
Glycosylation is an important protein post-translational modification. In this process, the intermediate product, Tn antigen, arises from somatic mutations in core1β3-galactosyltransferase-specific molecular chaperone (Cosmc), which is required for the formation of active core1β3-galactosyltransferase (T-synthase). As a type of tumor-associated carbohydrate… CONTINUE READING