CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain.

@article{Shih2001CD2APLT,
  title={CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain.},
  author={N Y Shih and Jiu-feng Li and Ramzi S. Cotran and Peter Mundel and Jeffrey H Miner and Andrey S Shaw},
  journal={The American journal of pathology},
  year={2001},
  volume={159 6},
  pages={
          2303-8
        }
}
  • N Y Shih, Jiu-feng Li, +3 authors Andrey S Shaw
  • Published in
    The American journal of…
    2001
  • Biology, Medicine
  • CD2AP, an adapter protein containing multiple SH3 domains, plays a critical role in kidney function. Mice lacking CD2AP die soon after birth because of kidney failure. In the kidney, CD2AP is expressed in glomerular podocytes, which suggests that it may play a role in a specialized adhesion complex known as the slit diaphragm. One of the major components of the slit diaphragm is nephrin, a podocyte-specific protein. Here we demonstrate that CD2AP localizes to the slit diaphragm in podocytes… CONTINUE READING

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