CD2AP/CMS Regulates Endosome Morphology and Traffic to the Degradative Pathway Through its Interaction with Rab4 and c‐Cbl

  title={CD2AP/CMS Regulates Endosome Morphology and Traffic to the Degradative Pathway Through its Interaction with Rab4 and c‐Cbl},
  author={M Cormont and Isidoro Met{\'o}n and Muriel C Mari and Pascale Monzo and Fr{\'e}d{\'e}rique Keslair and Chantell Gaskin and Timothy E. McGraw and Yannick Le Marchand-Brustel},
The small GTPase Rab4 is involved in endocytosis through sorting and recycling early endosomes. To better understand the role of Rab4 in regulation of vesicular trafficking, we searched for effectors that specifically interact with Rab4‐Q67L, the GTP‐bound form of Rab4. We cloned an ubiquitous 80‐kDa protein, identical to CD2‐associated protein/Cas ligand with multiple SH3 domains (CD2AP/CMS), that interacts with Rab4‐Q67L in the yeast two‐hybrid system and in vitro. CD2AP/CMS expressed in… 

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