CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs.

@article{Pagn2012CD28PC,
  title={CD28 promotes CD4+ T cell clonal expansion during infection independently of its YMNM and PYAP motifs.},
  author={Antonio J. Pag{\'a}n and Marion Pepper and Hamlet H. Chu and Jonathan Green and Marc K Jenkins},
  journal={Journal of immunology},
  year={2012},
  volume={189 6},
  pages={2909-17}
}
CD28 is required for maximal proliferation of CD4+ T cells stimulated through their TCRs. Two sites within the cytoplasmic tail of CD28, a YMNM sequence that recruits PI3K and activates NF-κB and a PYAP sequence that recruits Lck, are candidates as transducers of the signals responsible for these biological effects. We tested this proposition by tracking polyclonal peptide:MHCII-specific CD4+ T cells in vivo in mice with mutations in these sites. Mice lacking CD28 or its cytoplasmic tail had… CONTINUE READING

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