CD28-negative CD4+ and CD8+ T cells in antiretroviral therapy-naive HIV-infected adults enrolled in adult clinical trials group studies.

@article{Tassiopoulos2012CD28negativeCA,
  title={CD28-negative CD4+ and CD8+ T cells in antiretroviral therapy-naive HIV-infected adults enrolled in adult clinical trials group studies.},
  author={Katherine K Tassiopoulos and Alan L. Landay and Ann C Collier and Elizabeth Connick and Steven G. Deeks and Peter D. Hunt and Dorothy Ellen Lewis and Cara C Wilson and Ronald J. Bosch},
  journal={The Journal of infectious diseases},
  year={2012},
  volume={205 11},
  pages={
          1730-8
        }
}
BACKGROUND Individuals infected with human immunodeficiency virus (HIV) have higher risk than HIV-negative individuals for diseases associated with aging. T-cell senescence, characterized by expansion of cells lacking the costimulatory molecule CD28, has been hypothesized to mediate these risks. METHODS We measured the percentage of CD28(-)CD4(+) and CD8(+) T cells from HIV-infected treatment-naive adults from 5 Adult Clinical Trials Group (ACTG) antiretroviral therapy (ART) studies and the… CONTINUE READING

Figures, Tables, and Topics from this paper.

Citations

Publications citing this paper.
SHOWING 1-10 OF 20 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 25 REFERENCES

Immune senescence, activation, and abnormal T-cell homeostasis despite effective HAART, a hallmark of early aging in HIV disease

S Desai, R Ronquillo, X Usuga
  • Program and abstracts of the 16th Conference on Retroviruses and Opportunistic Infections;
  • 2009
VIEW 2 EXCERPTS

Incomplete reconstitution of T cell subsets on combination antiretroviral therapy in the AIDS Clinical Trials Group protocol 384.

  • Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2009
VIEW 1 EXCERPT

Premature aging of T cells is associated with faster HIV-1 disease progression.

  • Journal of acquired immune deficiency syndromes
  • 2009
VIEW 1 EXCERPT