CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers.

@article{Harhaj1996CD28MA,
  title={CD28 mediates a potent costimulatory signal for rapid degradation of IkappaBbeta which is associated with accelerated activation of various NF-kappaB/Rel heterodimers.},
  author={Edward William Harhaj and Sanjay B. Maggirwar and Laura Good and Shao-cong Sun},
  journal={Molecular and cellular biology},
  year={1996},
  volume={16 12},
  pages={
          6736-43
        }
}
Optimal activation of T cells requires at least two signals delivered by the T-cell receptor complex and costimulatory molecules such as CD28. The CD28 signaling participates in the transcription of the interleukin-2 gene through activation of an enhancer termed the CD28-responsive element (CD28RE). Stimulation of CD28 enhances mitogen-mediated induction of CD28RE-binding proteins including members of the NF-kappaB/Rel transcription factor family, although the underlying mechanism remains… CONTINUE READING
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