CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones
@article{Harding1992CD28mediatedSC, title={CD28-mediated signalling co-stimulates murine T cells and prevents induction of anergy in T-cell clones}, author={Fiona A Harding and James G. Mcarthur and Jane A. Gross and David H. Raulet and James P. Allison}, journal={Nature}, year={1992}, volume={356}, pages={607-609} }
OCCUPANCY of the T-cell antigen receptor is insufficient to induce T-cell activation optimally; a second co-stimulatory signal is required1. Exposure of T-cell clones to complexes of antigen with major histocompatibility complex molecules in the absence of the co-stimulatory signal induces a state of clonal anergy. This requirement for two stimuli for T-cell activation could have an important role in vivo in establishing peripheral tolerance to antigens not encountered in the thymus1,2. The…
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