CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86

@article{Orabona2004CD28II,
  title={CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86},
  author={C. Orabona and U. Grohmann and M. Belladonna and F. Fallarino and C. Vacca and R. Bianchi and S. Bozza and C. Volpi and B. Salomon and M. Fioretti and L. Romani and P. Puccetti},
  journal={Nature Immunology},
  year={2004},
  volume={5},
  pages={1134-1142}
}
  • C. Orabona, U. Grohmann, +9 authors P. Puccetti
  • Published 2004
  • Biology, Medicine
  • Nature Immunology
  • Bidirectional signaling along the B7–CTLA-4 coreceptor pathway enables reciprocal conditioning of T cells and dendritic cells. Although T cells can instruct dendritic cells to manifest tolerogenic properties after CTLA-4 engagement of B7, such a B7-mediated signaling is not known to occur in response to CD28. Here we show that mouse dendritic cells were induced by soluble CD28 to express interleukin 6 and interferon-γ. Production of interleukin 6 required B7-1 (CD80), B7-2 (CD86) and p38… CONTINUE READING
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