CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86

@article{Orabona2004CD28II,
  title={CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86},
  author={Ciriana Orabona and Ursula Grohmann and Maria Laura Belladonna and Francesca Fallarino and Carmine Vacca and Roberta Bianchi and Silvia Bozza and Claudia Volpi and Beno{\^i}t L. Salomon and Maria Cristina Fioretti and Luigina Romani and Paolo Puccetti},
  journal={Nature Immunology},
  year={2004},
  volume={5},
  pages={1134-1142}
}
Bidirectional signaling along the B7–CTLA-4 coreceptor pathway enables reciprocal conditioning of T cells and dendritic cells. Although T cells can instruct dendritic cells to manifest tolerogenic properties after CTLA-4 engagement of B7, such a B7-mediated signaling is not known to occur in response to CD28. Here we show that mouse dendritic cells were induced by soluble CD28 to express interleukin 6 and interferon-γ. Production of interleukin 6 required B7-1 (CD80), B7-2 (CD86) and p38… 

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