CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.

@article{Truitt1995CD28DC,
  title={CD28 delivers costimulatory signals independently of its association with phosphatidylinositol 3-kinase.},
  author={Kenneth E. Truitt and Jishu Shi and Spencer Gibson and Lynne Segal and Gordon B. Mills and John B. Imboden},
  journal={Journal of immunology},
  year={1995},
  volume={155 10},
  pages={4702-10}
}
CD28, a cell-surface molecule expressed by T cells, delivers costimulatory signals during the activation of T cells by Ag. Stimulation of CD28 induces its association with phosphatidylinositol 3'-kinase (PI3-K), raising the possibility that PI3-K plays a critical role in CD28 signaling. We find, however, that wortmannin, a potent inhibitor of PI3-K, does not block CD28-mediated costimulation of Jurkat (a human T cell line) or of murine CD4+ T cells. To address further the role of PI3-K in CD28… CONTINUE READING

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