CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis.

@article{OliveiradosSantos1999CD28CI,
  title={CD28 costimulation is crucial for the development of spontaneous autoimmune encephalomyelitis.},
  author={Antonio J. Oliveira-dos-Santos and Alexandra Ho and Yoshifumi Tada and Juan Jose Lafaille and Susumu Tonegawa and Tak W Mak and Joseph M. Penninger},
  journal={Journal of immunology},
  year={1999},
  volume={162 8},
  pages={4490-5}
}
Multiple sclerosis (MS) is a severe central nervous system disease. Experimental autoimmune encephalomyelitis (EAE) mimics MS in mice. We report that spontaneous development of EAE in RAG-1-deficient mice transgenic for a myelin basic protein (MBP)-specific TCR (TgMBP+/RAG-1-/-) requires expression of the T cell costimulatory molecule CD28. Surprisingly, T cells from CD28-/-TgMBP+/RAG-1-/- mice proliferate and produce IL-2 in response to MBP1-17 peptide in vitro, excluding clonal anergy as the… CONTINUE READING
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