CD28 costimulation and immunoaffinity-based selection efficiently generate primary gene-modified T cells for adoptive immunotherapy.

@article{Berger2003CD28CA,
  title={CD28 costimulation and immunoaffinity-based selection efficiently generate primary gene-modified T cells for adoptive immunotherapy.},
  author={Carolina Berger and C. Anthony Blau and Tim Clackson and Stanley R Riddell and Shelly Heimfeld},
  journal={Blood},
  year={2003},
  volume={101 2},
  pages={476-84}
}
The introduction of an inducible suicide gene has been proposed as a strategy to exploit the antitumor reactivity of donor T cells after allogeneic hematopoietic stem cell transplantation but permit control of graft-versus-host disease. However, there are several obstacles to this approach that may impair the ability of T cells to function and survive in vivo. These include the requirement for in vitro activation or long-term culture to introduce the transgene and obtain therapeutic cell… CONTINUE READING

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Hematopoietic stem-cell transplantation.

The New England journal of medicine • 2006

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