CD28 as a molecular amplifier extending TCR ligation and signaling capabilities.

@article{Michel2001CD28AA,
  title={CD28 as a molecular amplifier extending TCR ligation and signaling capabilities.},
  author={Fr{\'e}d{\'e}rique Michel and G{\'e}raldine Attal-Bonnefoy and Giorgio Mangino and Setsuko Mise-Omata and Oreste Acuto},
  journal={Immunity},
  year={2001},
  volume={15 6},
  pages={935-45}
}
Evidence has gathered that CD28 costimulation facilitates T cell activation by potentiating TCR intrinsic-signaling. However, the underlying molecular mechanism is largely unknown. Here we show that, by enhancing T cell/APC close contacts, CD28 facilitates TCR signal transduction. Moreover, the signal supplied by CD28 does not lead to increased Zap-70 and Lat phosphorylation, but amplifies PLCgamma1 activation and Ca(2+) response. We provide evidence that the PTK Itk controls the latter… CONTINUE READING

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