CD28 and T cell co-stimulation.

  title={CD28 and T cell co-stimulation.},
  author={Amy D. Holdorf and Osami Kanagawa and Andrey S Shaw},
  journal={Reviews in immunogenetics},
  volume={2 2},
Over the last decade the concept of T cell co-stimulation has emerged to take a central role in the process of T cell activation. However, the exact definition of co-stimulation is still unclear. In this review, we re-examine the concept of co-stimulation. We suggest that while co-stimulation is important, there is little evidence to link co-stimulation with T cell anergy. We then suggest a framework for studying co-stimulation. Focusing on recent advances in our understanding of CD28, we… CONTINUE READING

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