CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation

@inproceedings{Hnig2010CD28AI,
  title={CD28 and IL-4: two heavyweights controlling the balance between immunity and inflammation},
  author={Thomas H{\"u}nig and Fred L{\"u}hder and Karin Elflein and Tea Gogishvili and Monika Fr{\"o}hlich and Reto Guler and Antony J Cutler and Frank Brombacher},
  booktitle={Medical Microbiology and Immunology},
  year={2010}
}
The costimulatory receptor CD28 and IL-4Rα-containing cytokine receptors play key roles in controlling the size and quality of pathogen-specific immune responses. Thus, CD28-mediated costimulation is needed for effective primary T-cell expansion and for the generation and activation of regulatory T-cells (Treg cells), which protect from immunopathology. Similarly, IL-4Rα signals are required for alternative activation of macrophages, which counteract inflammation by type 1 responses… CONTINUE READING
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