CD28 and CD3 have complementary roles in T-cell traction forces.

Abstract

Mechanical forces have key roles in regulating activation of T cells and coordination of the adaptive immune response. A recent example is the ability of T cells to sense the rigidity of an underlying substrate through the T-cell receptor (TCR) coreceptor CD3 and CD28, a costimulation signal essential for cell activation. In this report, we show that these… (More)
DOI: 10.1073/pnas.1315606111

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