CD28 Costimulation Is Required for In Vivo Induction of Peripheral Tolerance in CD8 T Cells

@article{Vacchio2003CD28CI,
  title={CD28 Costimulation Is Required for In Vivo Induction of Peripheral Tolerance in CD8 T Cells},
  author={Melanie S Vacchio and Richard J Hodes},
  journal={The Journal of Experimental Medicine},
  year={2003},
  volume={197},
  pages={19 - 26}
}
Whereas ligation of CD28 is known to provide a critical costimulatory signal for activation of CD4 T cells, the requirement for CD28 as a costimulatory signal during activation of CD8 cells is less well defined. Even less is known about the involvement of CD28 signals during peripheral tolerance induction in CD8 T cells. In this study, comparison of T cell responses from CD28-deficient and CD28 wild-type H-Y-specific T cell receptor transgenic mice reveals that CD8 cells can proliferate… CONTINUE READING