CD28–B7 costimulation: a critical role for initiation and development of experimental autoimmune neuritis in C57BL/6 mice

@article{Zhu2001CD28B7CA,
  title={CD28–B7 costimulation: a critical role for initiation and development of experimental autoimmune neuritis in C57BL/6 mice},
  author={Yu Kun Zhu and Hampus Ljunggren and Eilhard Mix and Hu-lun Li and Jie Zhu},
  journal={Journal of Neuroimmunology},
  year={2001},
  volume={114},
  pages={114-121}
}
CD28 provides a critical costimulatory signal for antigen-specific T cell activation. Because CD28 is an important factor in the development of autoimmune diseases, we investigated its role in T cell-mediated experimental autoimmune neuritis (EAN), an animal model of Guillain-Barré syndrome in humans. CD28-deficient mutant (CD28-/-) C57BL/6 mice and corresponding wild-type mice were immunized with P0 peptide 180-199, a purified component of peripheral nerve myelin, and Freund's complete… CONTINUE READING
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