CD28/CTLA‐4–CD80/CD86 and ICOS–B7RP‐1 costimulatory pathway in bronchial asthma

  title={CD28/CTLA‐4–CD80/CD86 and ICOS–B7RP‐1 costimulatory pathway in bronchial asthma},
  author={Y-Q Chen and H-Z Shi},
Costimulatory molecules are cell surface glycoproteins that can direct, modulate and fine‐tune T‐cell receptor signals. The B7‐1/B7‐2–CD28/CTLA‐4 and ICOS–B7RP‐1 pathway provides key second signals that can regulate the activation, inhibition and fine‐tuning of T‐lymphocyte responses. The expression of B7‐1/B7‐2–CD28/CTLA‐4 molecules on clinical samples from patients with asthma have been well studied, and the results indicate that different extents of these molecules are expressed on the… 

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CD80 and CD86 knockdown in dendritic cells regulates Th1/Th2 cytokine production in asthmatic mice.

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Multiple In Vitro and In Vivo Regulatory Effects of Budesonide in CD4+ T Lymphocyte Subpopulations of Allergic Asthmatics

Budesonide modulates T cell survival, ICOS, Foxp3 and IL-10 molecules differently in T lymphocyte sub-populations in asthmatics and in vivo.

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The results suggest that CD6 has an important role in the regulation of CD5 tyrosine phosphorylation, probably due to its unique feature of associating with kinases of different families.

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In conclusion, inhibitory ligands of DC surface receptors and/or their cognate receptors on T cells could serve as useful tools in cell-based assays, directly influencing toxicological endpoints such as sensitization.

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