CD28/CTLA‐4–CD80/CD86 and ICOS–B7RP‐1 costimulatory pathway in bronchial asthma

@article{Chen2006CD28CTLA4CD80CD86AI,
  title={CD28/CTLA‐4–CD80/CD86 and ICOS–B7RP‐1 costimulatory pathway in bronchial asthma},
  author={Y-Q Chen and H-Z Shi},
  journal={Allergy},
  year={2006},
  volume={61}
}
Costimulatory molecules are cell surface glycoproteins that can direct, modulate and fine‐tune T‐cell receptor signals. The B7‐1/B7‐2–CD28/CTLA‐4 and ICOS–B7RP‐1 pathway provides key second signals that can regulate the activation, inhibition and fine‐tuning of T‐lymphocyte responses. The expression of B7‐1/B7‐2–CD28/CTLA‐4 molecules on clinical samples from patients with asthma have been well studied, and the results indicate that different extents of these molecules are expressed on the… 
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