CD27 in defining memory B-cell origins in Waldenström's macroglobulinemia.

  title={CD27 in defining memory B-cell origins in Waldenstr{\"o}m's macroglobulinemia.},
  author={Surinder Singh Sahota and Gavin Babbage and Nicola J Weston-Bell},
  journal={Clinical lymphoma & myeloma},
  volume={9 1},
CD27 is a tumor necrosis factor receptor family glycoprotein, identified in seminal studies as an apparently robust marker for normal memory B cells. Somatic hypermutation (SHM) in immunoglobulin variable (V) region genes, however, remains the definitive memory imprint. In Waldenström's macroglobulinemia (WM), SHM defines a predominant mutated (MUT) subset and a minor unmutated subset indicative of naive B-cell origin. In MUT-WM, tumor cells can lack CD27 expression, raising suggestions of… CONTINUE READING

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