CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development

  title={CD27 cooperates with the pre-T cell receptor in the regulation of murine T cell development},
  author={Loes A. Gravestein and Willem van Ewijk and Ferry A. Ossendorp and Jannie Borst},
  journal={The Journal of Experimental Medicine},
  pages={675 - 685}
CD27 is a lymphocyte-specific member of the TNF receptor family and has a TNF-related transmembrane ligand, CD70. The CD27/CD70 receptor-ligand pair cooperates with the TCR in the regulation of the peripheral T cell response. The study presented here reveals that CD27 may play a similar role in thymic pre-T cell development. We have previously cloned the cDNA encoding murine CD27, prepared specific mAbs and observed that murine CD27 is expressed on virtually all thymocytes, with the exception… CONTINUE READING


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