CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development.

@article{Oosterwijk2007CD27CD70IS,
  title={CD27-CD70 interactions sensitise naive CD4+ T cells for IL-12-induced Th1 cell development.},
  author={Michiel F. van Oosterwijk and Hedi Juwana and Ramon Arens and Kiki Tesselaar and Marinus H J van Oers and Eric Eldering and Ren{\'e} AW van Lier},
  journal={International immunology},
  year={2007},
  volume={19 6},
  pages={713-8}
}
Stimulation of CD27, a member of the tumour necrosis factor receptor family, by its ligand CD70 induces expansion of IFNgamma secreting CD4+ and CD8+ T cells in vivo. We here analysed the mechanisms through which CD27 mediates this effect. CD27 co-stimulation induced cell division but did not directly instruct naive CD4+ T cells to differentiate into IFNgamma-producing Th1 cells. Rather, in concert with signals delivered through the TCR-CD3 complex, CD27 co-stimulation enhanced the Th1-specific… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 45 extracted citations

Similar Papers

Loading similar papers…