CD26 (dipeptidyl-peptidase IV)-dependent recruitment of T cells in a rat asthma model.

  title={CD26 (dipeptidyl-peptidase IV)-dependent recruitment of T cells in a rat asthma model.},
  author={Carsten Kruschinski and Thomas Skripuletz and Sammy Bedoui and Thomas Tschernig and Reinhard Pabst and Christina Nassenstein and Armin Braun and Stephan von H{\"o}rsten},
  journal={Clinical and experimental immunology},
  volume={139 1},
CD26 truncates several chemokines as well as neuropeptides and influences immune responses via modulation of cell adhesion and T cell activation, suggesting an involvement of CD26 in asthmatic and airway inflammation. Therefore, Fischer 344 (F344), Brown Norway (BN) and Lewis (LEW) rat strains, which differ in their CD26-like enzymatic activity, were compared using an asthma model. Additionally, two CD26-deficient mutant F344 rat substrains were included and compared to the wild-type F344… CONTINUE READING


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