CD25 indicates the neoplastic phenotype of mast cells: a novel immunohistochemical marker for the diagnosis of systemic mastocytosis (SM) in routinely processed bone marrow biopsy specimens.

@article{Sotlar2004CD25IT,
  title={CD25 indicates the neoplastic phenotype of mast cells: a novel immunohistochemical marker for the diagnosis of systemic mastocytosis (SM) in routinely processed bone marrow biopsy specimens.},
  author={Karl Sotlar and H P Horny and Ingrid Simonitsch and Manuela Krokowski and Karl J. Aichberger and Matthias Mayerhofer and Dieter Printz and Gerhard Fritsch and Peter Valent},
  journal={The American journal of surgical pathology},
  year={2004},
  volume={28 10},
  pages={1319-25}
}
The diagnosis of systemic mastocytosis (SM) is based primarily on the histologic and immunohistochemical evaluation of a bone marrow trephine biopsy specimen. Although mast cell (MC) specific antigens like tryptase and chymase are detectable in routinely processed tissue, no immunohistochemical markers that can be used to discriminate between normal and neoplastic MCs are yet available. We have investigated the diagnostic value of an antibody against CD25 for the immunohistochemical detection… CONTINUE READING

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