CD25+ T cell depletion impairs murine squamous cell carcinoma development via modulation of antitumor immune responses.

@article{Ramos2012CD25TC,
  title={CD25+ T cell depletion impairs murine squamous cell carcinoma development via modulation of antitumor immune responses.},
  author={Rodrigo Nalio Ramos and Carine Ervolino de Oliveira and Tha{\'i}s Helena Gasparoto and Tatiana Salles de Souza Malaspina and Eduardo Bertoli Belai and Karen A Cavassani and Gustavo Pompermaier Garlet and Jo{\~a}o S. Silva and Ana Paula Campanelli},
  journal={Carcinogenesis},
  year={2012},
  volume={33 4},
  pages={
          902-9
        }
}
Squamous cell carcinoma (SCC) constitutes a microenvironment that could modulate the antitumor immune response. Also, tumor-infiltrating lymphocytes are believed to play complex regulatory roles in antitumor immunity against SCC. The presence of regulatory T cells (Tregs) has been associated with the suppression of tumor-reactive T cells. However, the underlying mechanism for this T cell dysfunction is not clear. We used a multistage model of SCC to examine the role of Treg cells during tumor… CONTINUE READING

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