CD247, a novel T cell-derived diagnostic and prognostic biomarker for detecting disease progression and severity in patients with type 2 diabetes.

@article{Eldor2015CD247AN,
  title={CD247, a novel T cell-derived diagnostic and prognostic biomarker for detecting disease progression and severity in patients with type 2 diabetes.},
  author={Roy Eldor and Yair Klieger and Moshe Sade-Feldman and Ilan Vaknin and Inna Varfolomeev and Camil Fuchs and Michal Baniyash},
  journal={Diabetes care},
  year={2015},
  volume={38 1},
  pages={
          113-8
        }
}
OBJECTIVE We have previously shown that chronic inflammation results in immunosuppression associated with CD247 downregulation in T lymphocytes. Type 2 diabetes mellitus (T2DM) is known to be associated with chronic inflammation. We therefore sought to examine CD247 expression levels in patients with T2DM and to assess whether it can serve as a diagnostic and prognostic biomarker for disease complications and outcomes. RESEARCH DESIGN AND METHODS Peripheral blood samples from 75 T2DM patients… CONTINUE READING
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