CD24 offers a therapeutic target for control of bladder cancer metastasis based on a requirement for lung colonization.

@article{Overdevest2011CD24OA,
  title={CD24 offers a therapeutic target for control of bladder cancer metastasis based on a requirement for lung colonization.},
  author={Jonathan B Overdevest and Shibu Thomas and Glen Kristiansen and Donna E Hansel and Steven Christopher Smith and Dan Theodorescu},
  journal={Cancer research},
  year={2011},
  volume={71 11},
  pages={3802-11}
}
Metastasis is lethal in most bladder cancer patients. Expression of CD24, a glycosyl phosphatidylinositol (GPI)-linked sialoglycoprotein and cancer stem cell marker, is associated with metastatic progression in multiple cancer types, yet the role of CD24 in this process remains unclear. While developing a murine model of human metastatic bladder cancer, we observed that tumor cell CD24 expression correlated with a propensity to metastasize to the lung. Our immunohistochemical evaluation of 60… CONTINUE READING

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References

Publications referenced by this paper.
Showing 1-10 of 47 references

Defining molecular profiles of poor outcome in patients with invasive bladder cancer using oligonucleotide microarrays.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2006
View 3 Excerpts
Highly Influenced

Selectins promote tumor metastasis.

Seminars in cancer biology • 2010
View 1 Excerpt

CD24 is a novel predictor for poor prognosis of hepatocellular carcinoma after surgery.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2009
View 1 Excerpt

Src phosphorylation of RhoGDI2 regulates its metastasis suppressor function.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 1 Excerpt

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