CD24 Expression Identifies Teratogen-Sensitive Fetal Neural Stem Cell Subpopulations: Evidence from Developmental Ethanol Exposure and Orthotopic Cell Transfer Models

@inproceedings{Tingling2013CD24EI,
  title={CD24 Expression Identifies Teratogen-Sensitive Fetal Neural Stem Cell Subpopulations: Evidence from Developmental Ethanol Exposure and Orthotopic Cell Transfer Models},
  author={Joseph D. Tingling and Shameena Bake and Rhonda Renay Holgate and Jeremy Alan Rawlings and Phillips P. Nagsuk and Jayashree A. Chandrasekharan and Sarah L. Schneider and Rajesh C Miranda},
  booktitle={PloS one},
  year={2013}
}
BACKGROUND Ethanol is a potent teratogen. Its adverse neural effects are partly mediated by disrupting fetal neurogenesis. The teratogenic process is poorly understood, and vulnerable neurogenic stages have not been identified. Identifying these is a prerequisite for therapeutic interventions to mitigate effects of teratogen exposures. METHODS We used flow cytometry and qRT-PCR to screen fetal mouse-derived neurosphere cultures for ethanol-sensitive neural stem cell (NSC) subpopulations, to… CONTINUE READING
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