CD23: An overlooked regulator of allergic disease

@article{Conrad2007CD23AO,
  title={CD23: An overlooked regulator of allergic disease},
  author={Daniel H. Conrad and Jill W. Ford and Jamie L Sturgill and David R. Gibb},
  journal={Current Allergy and Asthma Reports},
  year={2007},
  volume={7},
  pages={331-337}
}
Given the importance of immunoglobulin (Ig) E in mediating type I hypersensitivity, inhibiting IgE production would be a general way of controlling allergic disease. The low-affinity IgE receptor (FcɛRII or CD23) has long been proposed to be a natural regulator of IgE synthesis. In vivo research supporting this concept includes the observation that mice lacking CD23 have increased IgE production whereas mice overexpressing CD23 show strongly suppressed IgE responses. In addition, the finding… Expand
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