CD23/IgE-mediated regulation of the specific antibody response in vivo.

  title={CD23/IgE-mediated regulation of the specific antibody response in vivo.},
  author={Sven Gustavsson and S Hjulstr{\"o}m and T Liu and B Heyman},
  journal={Journal of immunology},
  volume={152 10},
We have recently reported that IgE Abs specific for TNP are able to enhance the specific IgG response in mice via the low affinity receptor for IgE, Fc epsilon RII, or CD23. In this study we show that IgE can up-regulate IgM, IgG1, IgG2a, and the IgE response, thereby indicating the possibility of a viscious circle in the maintenance of an allergic response. One of the suggested modes of action of IgE/CD23 is to increase the ability of B cells to present Ag to T cells. The involvement of T… CONTINUE READING

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